Proteomic analysis reveals sex-specific biomarker signature in
By A Mystery Man Writer
Description
Background Postural orthostatic tachycardia syndrome (POTS) is a variant of cardiovascular (CV) autonomic disorder of unknown etiology characterized by an excessive heart rate increase on standing and orthostatic intolerance. In this study we sought to identify novel CV biomarkers potentially implicated in POTS pathophysiology. Methods We conducted a nested case-control study within the Syncope Study of Unselected Population in Malmö (SYSTEMA) cohort including 396 patients (age range, 15–50 years) with either POTS (n = 113) or normal hemodynamic response during passive head-up-tilt test (n = 283). We used a targeted approach to explore changes in cardiovascular proteomics associated with POTS through a sequential two-stage process including supervised principal component analysis and univariate ANOVA with Bonferroni correction. Results POTS patients were younger (26 vs. 31 years; p < 0.001) and had lower BMI than controls. The discovery algorithm identified growth hormone (GH) and myoglobin (MB) as the most specific biomarker fingerprint for POTS. Plasma level of GH was higher (9.37 vs 8.37 of normalised protein expression units (NPX); p = 0.002), whereas MB was lower (4.86 vs 5.14 NPX; p = 0.002) in POTS compared with controls. In multivariate regression analysis, adjusted for age and BMI, and stratified by sex, lower MB level in men and higher GH level in women remained independently associated with POTS. Conclusions Cardiovascular proteomics analysis revealed sex-specific biomarker signature in POTS featured by higher plasma level of GH in women and lower plasma level of MB in men. These findings point to sex-specific immune-neuroendocrine dysregulation and deconditioning as potentially key pathophysiological traits underlying POTS.
![Proteomic analysis reveals sex-specific biomarker signature in](https://www.frontiersin.org/files/Articles/1341374/fnagi-16-1341374-HTML/image_m/fnagi-16-1341374-g001.jpg)
Frontiers Serum proteomic biomarker investigation of vascular
![Proteomic analysis reveals sex-specific biomarker signature in](https://media.springernature.com/m685/springer-static/image/art%3A10.1038%2Fs41598-022-24729-x/MediaObjects/41598_2022_24729_Fig2_HTML.png)
Plasma proteomic profiling in postural orthostatic tachycardia syndrome (POTS) reveals new disease pathways
![Proteomic analysis reveals sex-specific biomarker signature in](https://s3-eu-west-1.amazonaws.com/simple-education-app/production/uploads/ce7d3ca50498893f21e2e49f571f4b2631df602443582382362878214.png)
Study protocol for head-up tilt test (HUT)., o que é tilt test
![Proteomic analysis reveals sex-specific biomarker signature in](https://i1.rgstatic.net/publication/371794889_Predicting_Therapeutic_Efficacy_of_Pharmacological_Treatments_in_Children_with_Postural_Orthostatic_Tachycardia_Syndrome_A_Mini-Review/links/64959209c41fb852dd2736b0/largepreview.png)
PDF) Predicting Therapeutic Efficacy of Pharmacological Treatments in Children with Postural Orthostatic Tachycardia Syndrome: A Mini-Review
![Proteomic analysis reveals sex-specific biomarker signature in](https://pub.mdpi-res.com/ijms/ijms-24-07443/article_deploy/html/images/ijms-24-07443-g004.png?1682326055)
IJMS, Free Full-Text
![Proteomic analysis reveals sex-specific biomarker signature in](https://www.frontiersin.org/files/Articles/911997/fimmu-13-911997-HTML-r2/image_m/fimmu-13-911997-g001.jpg)
Frontiers Proteomic Analyses Reveal Higher Levels of Neutrophil
![Proteomic analysis reveals sex-specific biomarker signature in](https://www.researchgate.net/publication/365208972/figure/fig4/AS:11431281107466362@1671072551870/Potential-proteomic-biomarkers-associated-with-AD-The-diagram-shows-from-outside-to.png)
Potential proteomic biomarkers associated with AD. The diagram
![Proteomic analysis reveals sex-specific biomarker signature in](https://www.frontiersin.org/files/Articles/511281/fcvm-07-00021-HTML/image_m/fcvm-07-00021-g001.jpg)
Study protocol for head-up tilt test (HUT)., o que é tilt test
![Proteomic analysis reveals sex-specific biomarker signature in](https://www.researchgate.net/publication/372335268/figure/fig1/AS:11431281213352450@1702989408505/Renin-angiotensin-aldosterone-system-and-assessment-of-renin-activity_Q320.jpg)
Olle MELANDER, Lund University, Lund, LU, Department of Clinical Sciences, Malmö
![Proteomic analysis reveals sex-specific biomarker signature in](https://pub.mdpi-res.com/ijms/ijms-24-07443/article_deploy/html/images/ijms-24-07443-g001-550.jpg?1682326063)
IJMS, Free Full-Text
from
per adult (price varies by group size)