Mitotane (2,4′-DDD), Antineoplastic Agent
By A Mystery Man Writer
Description
Mitotane (2,4′-DDD), an isomer of DDD and derivative of dichlorodiphenyltrichloroethane (DDT), is an antineoplastic agent, can be used to research adrenocortical carcinoma. Mitotane exert its adrenocorticolytic effect at least in part through lipotoxicity induced by intracellular free cholesterol (FC) accumulation. Mitotane can have direct pituitary effects on corticotroph cells. Mitotane can induce CYP3A4 gene expression via steroid and xenobiotic receptor (SXR) activation, and has agent-agent interactions. - Mechanism of Action & Protocol.
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Cancers, Free Full-Text
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Mitotane induces drug metabolism genes in human liver. HepaRG cells (A
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The Challenging Pharmacokinetics of Mitotane: An Old Drug in Need of New Packaging
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Mitotane - an overview
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Mitotane cancer drug molecule. Skeletal formula Stock Vector Image & Art - Alamy
Mitotane, C14H10Cl4
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Exposure to anticancer drugs modulates the expression of ACSL4 and ABCG2 proteins in adrenocortical carcinoma cells - ScienceDirect
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Separations, Free Full-Text
Viability and apoptosis of H295R cells treated with mitotane and/or
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Pharmacological profile and effects of mitotane in adrenocortical carcinoma - Corso - 2021 - British Journal of Clinical Pharmacology - Wiley Online Library
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The effect of mitotane on viability, steroidogenesis and gene expression in NCI‑H295R adrenocortical cells
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Mitotane (2,4′-DDD), Antineoplastic Agent
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PDF) Association of mitotane with chylomicrons and serum lipoproteins: Practical implications for treatment of adrenocortical carcinoma
Mitotane - LiverTox - NCBI Bookshelf
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